In contrast to IFN-λ treatment, IFN-α treatment of this clone failed to induce the expression of the IFN-stimulated genes, Oasl2 (Fig. 2A) and Usp18 (Fig. 2B), and to protect against infection with TM967, a TMEV derivative expressing mCherry (Fig. 2C). Here, USP18 is linked to infection.