One of the more recently discovered causes of familial epilepsy is the Tre2/Bub2/Cdc16 (TBC)1 domain family member 24 (TBC1D24) gene; over 50 mutations are now associated with a range of inherited neurological disorders, including myoclonic epilepsy, epileptic encephalopathy and DOORS syndrome (deafness, onychodystrophy, osteodystrophy, mental retardation and seizures) (12,13). The gene discussed is TBC1D24; the disease is myoclonic epilepsy.