The change in the lipid metabolism is common in patients with diabetes and has been found to plays a key role in the pathogenesis of DPN.[16] The hepatic lipase activity, increased by the insulin resistance, hydrolyzes the phospholipids in the LDL and HDL particles and therefore causes smaller and denser LDL particles and decreased HDL.[20] Since the levels of LDL and triglyceride are usually high and the level of HDL is low in the patients with DPN, it was thought that there could be a relationship between these observations and the development of neuropathy. The gene discussed is LIPC; the disease is Insulin resistance.