IL18 and diabetes mellitus: IL-1, IL-6, IL-18, tumor necrosis factor-a1, interferon-1, transforming growth factor-1, and C-reactive protein are the inflammatory factors associated with the pathogenesis of diabetes.[44–46] These circulating factors reflect low-grade chronic inflammation and are associated with the diabetic complications.[47] However, their detection entails high costs, prohibiting their use in daily clinical practice.