This relationship can be seen through a recent study by Oliverio et al. that utilized BAT from Ames dwarf, Ercc1-/- (premature aging) and diet-induced obesity (DIO) mice to demonstrate that alterations in BAT microRNA profiles in Ercc1-/- and DIO mice are opposite to those of Ames dwarf mice [20]. Here, ERCC1 is linked to obesity due to melanocortin 4 receptor deficiency.