On the other hand, emerging evidence indicates vasoprotective and antiatherosclerotic functions for endothelial and cardiomyocyte Nox4 because deletion of Nox4 in these cell types is associated with worse cardiovascular injury and endothelial dysfunction in experimental models of atherosclerosis, cardiac ischemia, and hypertension (86, 134). This evidence concerns the gene NOX4 and atherosclerosis.