Another two studies reported that MELK expression is associated with tumor cell mitosis28 and promotes tumor cell proliferation.29 MELK also plays an important role in the P53‐P21 apoptotic pathway.30 Based on the above findings, we used different concentrations of inhibitor OTSSP167 and siRNA knockdown MELK to detect cervical cell proliferation, colony formation ability, and apoptosis‐related proteins P53, cleaved caspase‐3. The gene discussed is TP53; the disease is neoplasm.