Inhibitors of tumor DNA damage repair pathways can induce tumor DNA damage and increase the efficacy of chemoradiotherapy.31, 32, 33 Targeting MELK function through the inhibitor MELK‐T1 can reduce the DNA damage tolerance threshold and make the tumor sensitive to DNA damaging agents or radiation therapy.21 MELK can increase the resistance to the radiation and 5‐FU treatments in colorectal cancer cells.34 MELK inhibition may be a novel and favorable strategy for chemoradiotherapy in cancers. Here, MELK is linked to colorectal cancer.