Transcriptome‐wide association study analysis identified 19 genes significantly associated with PC, such as LRP5L (P value = 5.21 × 10‐5), SOX4 (P value = 3.2 × 10‐4), and EGLN3 (P value = 6.2 × 10‐3). The gene discussed is LRP5L; the disease is pachyonychia congenita.