For instance, it has been demonstrated that TGF‐beta signaling pathway in pancreatic cancer can be utilized in targeted therapy clinical trials.32 Another interesting pathway is one carbon pool by folate, which is associated with influenced PC incidence.33 Researchers have also proved that aminoacyl‐tRNA biosynthesis, metabolic pathways, cell cycle, tight junction, purine metabolism, and mRNA surveillance pathway are existed in PC cells and related to occurrence and development of PC.33, 34, 35, 36, 37, 38 The rest of these signaling pathways are solid tumor directly. This evidence concerns the gene TGFB1 and pachyonychia congenita.