Transcriptome‐wide association study analysis identified several novel candidate genes for PC, such as RP11‐65J3.1, PPFIBP2, GEMIN4, NIPA2,RNASEH2B, FARS2, MTHFD1L, F2R, TXNDC15, NDUFA3, CRISPLD2, IQSEC3, and LRP5L. This evidence concerns the gene FARS2 and pachyonychia congenita.