Transcriptome‐wide association study analysis identified several novel candidate genes for PC, such as RP11‐65J3.1, PPFIBP2, GEMIN4, NIPA2,RNASEH2B, FARS2, MTHFD1L, F2R, TXNDC15, NDUFA3, CRISPLD2, IQSEC3, and LRP5L. This evidence concerns the gene TXNDC15 and pachyonychia congenita.