Transcriptome‐wide association study analysis identified several novel candidate genes for PC, such as RP11‐65J3.1, PPFIBP2, GEMIN4, NIPA2,RNASEH2B, FARS2, MTHFD1L, F2R, TXNDC15, NDUFA3, CRISPLD2, IQSEC3, and LRP5L. The gene discussed is PPFIBP2; the disease is pachyonychia congenita.