A NanA mutant is cleared from the nasopharynx, trachea, and lungs within 12 hours post‐infection and is unable to persist in the blood beyond 48 hours post‐infection in vivo.39 Biofilm formation facilitates the ability of S. pneumoniae to evade complement immunity and phagocytosis by diverting alternative complement pathway activation through a PspC‐mediated mechanism.40 Additionally, Trappetti et al proved that sialic acid is a pivotal signal for the pneumococcal biofilm formation, colonisation, and host invasion.5 Here, SFTPC is linked to infection.