Mechanistically, previous work has noted a sex‐dependent effect of MET on serum PRL levels, and suggested the involvement of thyroid's secretory axis as well as the central dopaminergic transmission.29 We found here for the first time that MET suppresses ERα and ERβ expression in PRLoma cells and their xenografts. This evidence concerns the gene PRL and prolactin-producing pituitary gland adenoma.