Previous studies reported a role of AMPK activator MET and AICAR in suppressing proliferation and growth hormone secretion of GH3 as a model of growth hormone‐secreting pituitary adenoma, but observed different effect of the drug on cell apoptosis.24, 25, 26, 27 How MET and AMPK activation may affect PRLoma, eg, the PRL secretion and the phenotype of other PRLoma cells remain largely unclear. This evidence concerns the gene GH1 and prolactin-producing pituitary gland adenoma.