CREBBP and Rubinstein-Taybi syndrome: Studying the role of CBP in interneuron production and maturation has important clinical implications because hemizygous mutations in the human version of the gene (CREBBP) cause a severe intellectual disability disorder known as Rubinstein-Taybi syndrome (RSTS; OMIM #180849) that is associated with electroencephalographic anomalies in more than half of the diagnosed individuals.