It would be interesting to determine whether restricted ablation of Nkx2-1 and Lhx6 in MGE neuroprogenitors, which cause seizure phenotypes and abnormal electroencephalographic activity [28, 29], also leads to cognitive impairments similar to the ones observed here for Nkx2.1-CBPKO mice. Here, NKX2-1 is linked to Cognitive impairment.