Hoorn EJ et al. postulated a new mechanistic pathway of hyperkalemia in transplant recipients by demonstrating that tacrolimus activates the thiazide-sensitive sodium-chloride cotransporter (NCC) in the distal convoluted tubule (DCT) leading to hyperkalemia and hypertension similar to the ones that occur in Gordon syndrome (13). Here, SLC12A3 is linked to hypertensive disorder.