Since diet-induced obesity alters bone remodeling leading to decreased femoral trabecular bone mass in mice (Cao et al., 2009, 2010; Halade et al., 2011; Patsch et al., 2011; Picke et al., 2018b), we investigated the impact of Thy-1 on the disturbed bone remodeling in obesity. Here, THY1 is linked to obesity due to melanocortin 4 receptor deficiency.