Although multiple studies have analyzed susceptibility and resistance genes associated to the development of the lesions (Castellucci et al., 2012; Sohrabi et al., 2013; Abdoli et al., 2017), the role of EGF, FGF, and PDGF in the establishment of the infection, development of the ulcer, and in early response to treatment has not been established. Here, EGF is linked to ulcer disease.