Based on the important role of growth factors during healing and tissue repair, this study aimed to identify the expression levels of EGF, FGF, PDGF, and TGFβ1 during: (i) infection by Leishmania (V) braziliensis, (ii) development of CL, and (iii) early response to treatment using the experimental model for CL in the golden hamster (Mesocricetus auratus). Here, EGF is linked to infection.