It has been confirmed in the hamster model for CL that infection by Leishmania generates the activation of the Nlrp3 inflammasome with the subsequent production of IL1β (Lima-Junior et al., 2013), and this cytokine may negatively regulate the expression of PDGF (Barrientos et al., 2008; Mundy, 2009). The gene discussed is NLRP3; the disease is infection.