Studies carried out with other types of ulcers reported that during healing, the epidermal tissue is formed after transformation of the dermis into fibrous tissue (scarring) accompanied by an increase in NK cells, a decrease in circulating T cells with depletion of CD8+ T cells, and a decrease of CD4+ T cells with a decrease in the production of IFNγ (Lakhal-Naouar et al., 2015) and expression of dermal and epidermal growth factors (Kiwanuka et al., 2012). This evidence concerns the gene IFNG and ulcer disease.