As shown in Figure 4A, it is observed that treatment of HNSCC cells with curcumin caused a decrease in expression levels of anti-apoptotic Bcl-2 protein with a subsequent increase in expression level of pro-apoptotic protein Bax indicating that curcumin-mediated expression of Bax and downregulation of Bcl2 play a role in curcumin induced apoptosis. The gene discussed is BAX; the disease is head and neck squamous cell carcinoma.