SKP2 and head and neck cancer: In the current study, we have elucidated that S-phase kinase-associated protein 2 (Skp2) could be a potential target for the treatment of head and neck cancer by using curcumin, a natural compound isolated from rhizomes of the plant Curcuma longa, and is the most commonly used food additive with strong anti-oxidant, anti-inflammatory, anti-microbial, hypoglycemic, and wound-healing activities (11).