Aldi-2 as well as the dyclonine analogs BAS00363846, PHAR033081, PHAR298639, and STL327701 were found to enhance the antiproliferative effects of sulfasalazine and the GSH synthesis inhibitor BSO in HSC-4 cells (Figure 2B), suggesting that such covalent ALDH inhibition might play a role in the cytotoxic action of this drug in GSH-depleted cancer cells. The gene discussed is LDHA; the disease is cancer.