Supplementary Figure 4 shows that RND1 expression is inversely correlated with common mesenchymal genes [30–33] and specific glioma mesenchymal genes [28, 29, 34]. These results clearly demonstrated that a lower expression of RND1 correlates with a higher expression of mesenchymal genes and, is a factor of poor prognosis for glioblastoma patients. Here, RND1 is linked to central nervous system cancer.