In colon cancer cells, TGIF2 directly interacts with PKM2 in the nucleus by EMT stimulation, and recruits histone deacetylase 3 to the CDH1 (E-cadherin) promoter sequence, which subsequently deacetylates histone H3 and suppresses CDH1 transcription [13]. The gene discussed is HDAC3; the disease is malignant colon neoplasm.