Although nine single nucleotide polymorphisms (SNPs) within the human FOXP3 gene show no significant associations to JIA (14) (suggesting these do not impact on FOXP3 in JIA), a key FOXP3-binding partner, Runt-related transcription factor 1 (RUNX1), is, however, significantly associated. Here, RUNX1 is linked to juvenile idiopathic arthritis.