Moreover, the SFTPB 1580_C (rs1130866) genetic variant has been observed to be a risk factor in several lung disease, such as idiopathic pulmonary fibrosis (IPF) (61), chronic obstructive pulmonary disease (COPD) (17), acute respiratory distress syndrome (ARDS) (137), septic shock and those with risk of respiratory failure after community acquired pneumonia (144), as well as increases mortality, apoptosis, and lung injury in mice carrying the human SP-B 1580_C variant compared to those with the 1580-T variant (145). Here, SFTPB is linked to chronic obstructive pulmonary disease.