Although no single SFTPA1 SNP by itself is associated with CF, the SFTPA1 rs1136451 SNP in an intragenic interaction with either SNP rs1059057 or rs4253527 is shown to associate with CF (X2 = 2.7329, 9 = 0.0469 or X2 = 3.5625, p = 0.0238, respectively) (Table 3). Here, SFTPA1 is linked to cystic fibrosis.