On the other hand, these results indicate that tumor-derived oxysterols may shape the TME inducing a pro-tumor milieu, as confirmed by the detection in the TME of Mock-4T1 tumors of higher levels of the type-2 cytokine transcripts Il4, Il13, as well as the anti-inflammatory Il10 transcripts (30) (Figure 3). Here, IL13 is linked to neoplasm.