Because stress induces increased expression of MICA and MICB on human intestinal epithelial cell lines (40), enhanced expression of murine NKG2D ligands on intestinal epithelial cells of DSS-treated Yeti/CD1d KO mice might trigger NK1.1+CD8+ T cell activation, which in turn might exacerbate DSS-induced colitis. The gene discussed is CFDP1; the disease is colitis.