CD8A and colitis: Importantly, adoptive transfer of IL15-induced NK1.1+CD8+ T cells resulted in a significant increase in DSS-induced weight loss and DAI score in the absence of iNKT cells, whereas DSS-induced colitis exacerbated by injection of IL15-induced NK1.1+CD8+ T cells was dramatically halted by the presence of iNKT cells (Figure 5E).