As B cells of some CVID subjects carry heterozygous TNFRSF13B mutations, we then examined complexes in HEK-293T cells transfected with either mCherry-labeled TACI-S or TACI-L, along with either isoform containing missense mutations found in CVID (C104R, A181E, or S194X) or YFP-CD40L as control. This evidence concerns the gene CD40LG and common variable immunodeficiency.