Fourth, although considered the active multimer of adiponectin with more relevance to protect against insulin resistance (Oh et al., 2007), the impact of high-molecular-weight ADPQ on MetS diagnosis and prediction cannot be pooled and compared with total ADPQ in less eligible publications (Seino et al., 2009; Nakashima et al., 2011). The gene discussed is ADIPOQ; the disease is Insulin resistance.