TP53 and breast cancer: Because the degradation speed of mutated p53 was significantly reduced, p53 expression was highly elevated in MDA-MB-231 cells compared with MCF-7 cells (Supplementary Figure S5); however, ADQ had little effect on p53 expression in both breast cancer cells (Supplementary Figure S6), indicating that the susceptibility of MDA-MB-231 or MCF-7 cells to ADQ was not related to p53 genetic status.