EGFR and cancer: In Figure 8D, KEGG analysis (P < 0.05) indicated that multiple cancer-related pathways were significantly involved in the mechanisms of ADQ including focal adhesion, apoptosis, cell cycle, p53, HIF-1, ErbB, phosphoinositide 3-kinase (PI3K)/Akt, Janus kinase/signal transducer and activator of transcription, mammalian target of rapamycin, NF-kappa B, and tumor necrosis factor signaling pathways.