However, as to glioma cells in vitro, DXM demonstrates opposite effects as it decreases TMZ-induced apoptosis in human gliobastoma T98G cells (Sur et al., 2005); inhibits glioma cell proliferation in a concentration and species-dependent manner and reduces tumour-induced angiogenesis (Fan et al., 2014), decreases MMP-2 secretion and invasiveness of human U87MG glioma cells (Lin et al., 2008) and suppresses the dispersal of GBM cells through the stimulation of fibronectin secretion and inhibition of the glioma cells motility (Shannon et al., 2015). Here, MMP2 is linked to central nervous system cancer.