Despite both heterozygous and homozygous Q175 mice generally have less aggressive phenotype than some other HD mouse models, they nonetheless recapitulate main manifestations of HD in humans, such as progressive accumulation of mutant huntingtin aggregates in striatal and cortical neurones, synapse loss, striatal and cortical atrophy, altered brain metabolic profile, decreased body weight and motor impairments (Oakeshott et al., 2011; Heikkinen et al., 2012; Menalled et al., 2012; Peng et al., 2016). This evidence concerns the gene HTT and Huntington disease.