TLR9 and Alzheimer disease: In an AD mouse model, activation of TLR9 by CpG ODN appears to be involved in the enhanced Aβ ingestion by microglia, which reduces Aβ aggregation and improves memory impairment (Iribarren et al., 2005; Tahara et al., 2006; Doi et al., 2009; Scholtzova et al., 2009).