STK11 and neoplasm: Although LKB1-mediated receptor sorting has not been demonstrated in other types of neuronal cells, LKB1 in lung cells promotes the cellular trafficking of the angiogenic receptor neuropilin-1, which is also involved in neurite development and neural migration, from the endosome to the lysosome for degradation, leading to attenuation of tumor angiogenesis and growth (Okon et al., 2014).