Fragile X Syndrome (FXS), the most common single-gene cause of intellectual disability, autism and epilepsy (Garber et al., 2008), is caused by transcriptional silencing of the FMR1 gene coding for Fragile X Mental Retardation Protein (FMRP), an mRNA-binding protein that regulates translation of several synaptic proteins (Pfeiffer and Huber, 2009). Here, FMR1 is linked to autism.