IGF1 and diabetes mellitus: Based on this investigation, we illustrated that adiponectin is necessary to facilitate exercise-mediated hippocampal neurogenesis; hence, future study on the changes at the molecular level, such as serum and hippocampal adiponectin levels, hippocampal BDNF and IGF-1 levels, hippocampal mRNA expressions of AdipoR1 and R2, by comparing the effects of physical exercise and STZ-induced diabetics in WT and adiponectin knockout mice will be useful to connect the adipocyte-brain axis.