In addition, in vitro research has shown that trimeric adiponectin promotes cell proliferation through AdipoR1-APPL1-pAMPK cascade in the adult mouse hippocampal DG-isolated neural progenitors and in Neuro2a neuroblastoma (Yau et al., 2014) and recombinant globular adiponectin stimulates p38 mitogen-activated protein kinase (p38MAPK)-glycogen synthase kinase 3 β (GSK-3 β)- β -catenin signaling cascade in the adult rat hippocampus-isolated neural progenitors (Zhang et al., 2011). Here, APPL1 is linked to neuroblastoma.