MKI67 and diabetes mellitus: Results of the two-way ANOVA analysis testing the hypothesis that running restores diabetes-impaired hippocampal neurogenesis revealed significant main effects for running condition and STZ on cell proliferation in the DG (Figure 3A; BrdU: main effect for STZ: F3,22 = 20.06, P < 0.0005; main effect for running: F3,22 = 13.83, P < 0.005; Figures 3B,C; Ki67: main effect for STZ: F3,20 = 30.40, P < 0.0001; main effect for running: F3,20 = 25.41, P = 0.0001).