ADIPOQ and type 2 diabetes mellitus: It has been reported that decreased adiponectin levels and hyper-activation of the hypothalamic-pituitary-adrenal (HPA) axis are concomitant in both T2DM and depressed patients (Roy et al., 1990; Leo et al., 2006; Narita et al., 2006; Yilmaz, 2008).