Consistent with these findings, the adiponectin haploinsufficient mouse model is more susceptible to stress-induced depressive disorders, and intracerebroventricular injection of adiponectin or recombinant adenovirus-expressing adiponectin has been shown to restore neuroplasticity and depression-like behaviors in both adiponectin haploinsufficient and deficient mouse models (Yau et al., 2011; Liu et al., 2012). This evidence concerns the gene ADIPOQ and depressive disorder.