Deficits of retention of these memories seems to occur at later stages of AD, between 7 and 9 months in PS1-APP mutant mice (Roy et al., 2016) and only deficits of intra-session acquisition were found earlier, at 4 months of age in AβPPswe/PS1ΔE9 mice (Maroof et al., 2014). Here, APP is linked to Alzheimer disease.