CNR1 and Cognitive impairment: Curiously, another non-selective agonist of CB1R, curcumin (an antioxidant polyphenol) (Witkin et al., 2013) prevented cognitive deficits when administered for 30 consecutive days after icv-STZ injection (Bassani et al., 2017) and when tested in vitro curcumin up-regulated BAG2 levels and reduced p-tau levels (Patil et al., 2013).