To assess whether imatinib also affects liver macrophages, which are key drivers of NAFLD, we performed a time-resolved study with HFD-induced obese mice (data summarized in Table 1): Concurrent with TNFα-reduction in peritoneal macrophages, imatinib lowered TNFα gene expression in liver tissue after one month. Here, TNF is linked to metabolic dysfunction-associated steatotic liver disease.