The major finding in this large cross-sectional study was that circulating TNF-related inflammatory biomarkers (TNFα, PGRN, TNFR1, and TNFR2) were associated with two important renal traits (ACR and eGFR) in Japanese patients with T2D and an eGFR ≥30 mL/min/1.73 m2. Here, TNFRSF1A is linked to type 2 diabetes mellitus.