TNFRSF1A and diabetes mellitus: Circulating levels of TNF receptors (TNFRs; TNFR1, TNFR2), which are the surface receptors of TNFα, in patients with diabetes have been associated with renal traits (albuminuria and eGFR) as well as cardiovascular disease (CVD) and all-cause mortality in both cross-sectional and longitudinal studies4–16.