Upon application of a SPINK1-specific monoclonal antibody (SPINK1 mAb), a significantly decreased cellular viability of PCa cells was observed, with the effect comparable to or even higher than that of either AG-1478 or cetuximab, the latter a food and drug administration (FDA)-approved EGFR-targeting monoclonal antibody (Fig. 4g). This evidence concerns the gene SPINK1 and posterior cortical atrophy.