Further analysis indicated the emergence of advanced malignancies including epithelial–mesenchymal transition (EMT) and cancer stem cell (CSC) appearance, both occurring in parallel with the EET process, as supported by the upregulation of CD31 and CD34, vascular lineage markers indicative of neoangiogenesis38 (Fig. 5g; Supplementary Fig. 5h). This evidence concerns the gene PECAM1 and cancer.