Furthermore, PSC27SPINK1 CM-treated cells displayed an apparent change from a typical epithelial to spindle-like or mesenchymal shape, a process accompanied by decreased CDH1 (E-cadherin) but increased CDH2 (N-cadherin) and vimentin expression, implying a prominent EMT transition that occurs in cancer cells upon SPINK1-exposure (Fig. 5h, i; Supplementary Fig. 5i). Here, SPINK1 is linked to cancer.