Interestingly, some of the SASP factors such as AREG and ANGPTL4, together with the typical senescence markers including p16 and p21, were co-expressed in stromal and cancer epithelial cells, suggesting drug treatment induced comprehensive in vivo cellular senescence, although the SASP profile seemed to develop differently between stromal and cancer cells (Fig. 6c). This evidence concerns the gene ANGPTL4 and cancer.