SPINK1 and posterior cortical atrophy: Although culturing with the CM of BLEO-treated PSC27 (PSC27-BLEO) increased proliferation, migration, and invasiveness of PCa cells, SPINK1 clearance from stromal cells significantly diminished such malignancy-enhancing capacities of PSC27-BLEO CM, with a reduction of 30–35% in each assayed phenotype (Fig. 4d–f).