MYC-induced nuclear antigen (MINA531, also known as Mdig2, NO523, RIOX2) is a JmjC (jumonji C domain)-containing protein which is highly expressed in many cancers, such as pancreatic cancer4, gastric adenocarcinoma5, lung cancer6,7, lymph cancer8, colon cancer9, esophageal squamous cell carcinoma10, neuroblastoma11, and cholangiocarcinoma12. The gene discussed is RIOX2; the disease is cancer.