RIOX2 and glioblastoma: These results were consistent with our results above (Figs. 3e and 4d) and further demonstrated that knockdown of MINA53 sensitized glioblastoma cells to Doxorubicin; after treated with Doxorubicin, glioblastoma cells with MINA53 knocked down suffered severer DNA damage and diminished DDR and ultimately died through cell apoptosis.