FURIN and infection: The TG mice (2.844 ± 0.1416) showed an increase in AP frequency compared with the WT mice (1.765 ± 0.2098), while LV-sh-furin infection (1.019 ± 0.1744) resulted in a decrease in AP frequency compared with Con-shRNA (1.602 ± 0.1738) (n = 6 in each group, *P < 0.05, ***P < 0.001, Fig. 5a).To assess excitatory synaptic transmission, we recorded the miniature excitatory postsynaptic currents (mEPSCs).