RIGI and Zika virus infectious disease: These results were confirmed by qRT-PCR analysis, showing upregulated expression of IFNB, MX1, IP-10, CH25H, ISG15, OASL, IFITM3, RIG-I, and TRIM21 following ZIKV infection at 24 hpi but not 12 hpi (Fig. 4e and Fig. S11b–g), in agreement with previous findings in A549 cells29.