Prp8 appears to be required for Ras-driven hyperplasia and this role appears to be conserved with other oncogenes, such as activated Egfr and N. Therefore, our data extends recent observations in the context of human cancers, in which the spliceosome has been identified as a potential therapeutic target in Myc-driven tumours (Hsu et al., 2015). Here, PRPF8 is linked to cancer.