Moreover, the expression of Cd274 was well correlated with the respective expression of Ifng, Irf1, Gbp5, and Ccl2 (Fig. 5c), demonstrating that selected IFN-γ-induced genes serve as feasible substitute indicators for IFN-γ level and thus might synergistically indicate the prognosis of glioma. This evidence concerns the gene IRF1 and central nervous system cancer.