EGFR and lung carcinoma: According to Amiji et al., epidermal growth factor receptor (EGFR) was overexpressed in the human lung carcinoma A549 cell line, and EGFR-targeted nanoparticles have been developed from CS with a PEG linker that silenced the essential mitotic checkpoint gene Mad2 alone or in combination with cisplatin at subtherapeutic doses [64].