Furthermore, the observation that the infection of HFFs with the v65Stop HCMV mutant leads to the induction of both NF-κB DNA binding and transcriptional activities at promoter regions of IL-1β, thereby enhancing the production of IL-1β, strongly argues in favor of an inhibitory role that is played by HCMV pp65 during IL-1β production. Here, NFKB1 is linked to infection.