STON2 and autoimmune disease: Genetic variation controlling T helper cell subsets with crucial roles in protection against infection and susceptibility to autoimmune disease include the second mTOR signaling complex (RICTOR) and endocytosis-related stonin 2 (STON2) associated with Th2 and Th17, respectively, and the interferon-lambda locus controlling regulatory T (Treg) cell proliferation.