TNF and systemic sclerosis: Suggestive associations in the human leukocyte antigen (HLA) region overlapping with disease loci (Tables 3 and S6) included the above-described variant for TNF-α levels and a risk variant for systemic sclerosis near HLA-DRB5 and HLA-DRB6 (Gorlova et al., 2011) associated with a higher percentage of lymphocytes.