Examples are STON2 inhibition to lower Th17 levels critical in several autoimmune diseases, RICTOR stimulation to induce an anti-inflammatory and pro-regenerative context, or RICTOR inhibition in the case of Th2-mediated allergy or asthma, interferon-lambda provision to stimulate the proliferation of existing Treg cells (an attractive therapeutic intervention point for autoimmune disorders), blockade of early B cell differentiation by the La-related family homolog LARP1B, and blockade of exocytosis and release of pro-inflammatory cytokines by interfering with the latrophilin ADGRL2. The gene discussed is ADGRL2; the disease is asthma.