More than half of discharges (55%) with >1 PCT order had an extreme APR-DRG severity of illness score; 42% of discharges with 1 PCT, 40% of discharges with at least one CRP and/or lactate, and 25% of discharges with no-sepsis biomarker orders had an extreme APR-DRG severity of illness score. The gene discussed is CRP; the disease is Sepsis.