These findings are in agreement with 2 recent studies: (1) Hinson and co-workers showed that iPSC-CM generated from DCM patient carrying the pP22582fs+/- titin mutation (different than the AuP and IsP mutations) demonstrated diminished responses to β-adrenergic stress using contractile function assay [35]. The gene discussed is TTN; the disease is familial dilated cardiomyopathy.