LDLR and familial hyperaldosteronism: The selection of the p.(Cys46Gly) LDLr variant was based on three criteria: our interest in studying mutations in LR1 region that could have a pathogenic effect (despite this region has been considered no essential for LDLr activity[10, 17], previous documentation of this variant in FH patients, and, obviously, to study a variant whose effect has not been characterized before.