INS and neoplasm: The pairing of lifestyle interventions with pharmacological therapies such as aspirin, which inhibits platelet aggregation decreasing the ability for CTCs to bind to the endothelium (i.e., altering the mechanical efficiency of extravasation) [41], or metformin to reduce insulin (i.e., altering the host tumor microenvironment through growth factor suppression) [42], warrant investigation as synergy may exist between two complementary interventions.