For example, for this study, we used core cerebrospinal fluid (CSF) biomarkers of AD, such as amyloid β1–42 (Aβ1–42), total tau (t‐tau), and tau phosphorylated at epitope 181 (p‐tau181), and potential CSF biomarkers, such as tau phosphorylated at epitopes 199 (p‐tau199), and 231 (p‐tau231), and visinin‐like protein 1 (VILIP‐1) as endophenotypes. Here, MAPT is linked to Alzheimer disease.