In addition to apolipoprotein E gene (APOE), more than 20 common loci have been associated with risk for sporadic AD, age at onset, and progression of cognitive decline, but reported genome‐wide significant loci do not account for all the estimated heritability and provide little information about underlying biological mechanisms (Šimić et al., 2016a, 2016b). Here, APOE is linked to Mental deterioration.