We therefore also used an Emx1-Cre driver line (24) to delete Dot1l. Nissl staining of Emx1-Cre induced Dot1l-cKO at P0 showed that microcephaly was less obvious in these mutant brains compared to Foxg1-Cre mediated deletion of DOT1L. Here, DOT1L is linked to microcephaly.