However, hyperglycemia is present in as a response to surgical trauma.Surgical aggression triggers a neuroendocrine and metabolic reaction with changesthat translate into a hypercatabolic state, with elevated plasma levels of catabolichormones (cortisol, glucagon, catecholamines) and hormone release by thehypothalamus stimulating the release of adrenocorticotrophic hormone, growthhormone, prolactin, endorphins and antidiuretic hormone by the pituitary. This evidence concerns the gene GCG and Hyperglycemia.