In 2006, Heon Seo et al. 53 observed that PAF led to an increase in the protein levels of the antiapoptotic proteins Bcl-2 and Bcl-xL in B16F10 melanoma cells and that costimulation of tumor cells with PAF and the chemotherapeutic drug etoposide protected melanoma cells from etoposide-induced cell death in an NFkB-dependent manner. This evidence concerns the gene BCL2 and melanoma.