In primary oral squamous cell carcinoma (OSCC), the enzyme responsible for PAF synthesis, LPCAT1, is overexpressed compared to that in normal tissue, and its silencing decreased tumor cell proliferation and invasiveness 29, indicating that the PAF/PAFR axis is responsible for sustained prosurvival and proliferative signaling in malignant cells. The gene discussed is PTAFR; the disease is neoplasm.